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Principal Research Technician/Lab Manager - Center for Patient Derived Models

Dana-Farber Cancer Institute
Boston

Job Description

The Center for Patient Derived Models (CPCM) at DFCI is seeking applicants for the position of Principal Research Technician/Lab Manager. This is an exciting new initiative at the DFCI which seeks to advance modeling science by performing research on patient derived cell lines, xenografts, and acute cell sample preparations. Applicants must have prior experience in laboratory research in both in vitro and in vivo methods. The applicant will work to advance our knowledge of precision medicine, cancer biology, treatment and diagnostics in all cancer types of adults and children. Applicants hired to this position will apply modern cutting-edge techniques to study and create patient derived models of cancer (patient derived cell lines, patient derived xenografts, and cancer immunotherapy models, and Avatars).

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

The position will involve use of genomics, and functional testing to develop models that can aid in novel targeted therapy development and diagnosis of treatment effects.

Applicants will participate in clinical trials execution and support and preclinical studies. Applicants with prior experience in animal research and procedures (mouse/PDX, in vivo imaging, small animal surgery), cell culture (conventional and primary cell culture), preclinical, human research, pathology, and drug screening techniques and above methods are preferred.

The applicant will ensure protocols and/or amendments are in place and are accurate relative to the study design prior to study initiation. Improves experimental procedures if necessary through discussion with Centers Director, Associate Director and collaborating partners. The applicant will have project management responsibilities.

The applicant will lead and maintain a professional laboratory and vivarium environment required for various in vitro and in vivo research activities. The applicant will train/guide/assist new and junior lab members for commonly performed laboratory and animal related techniques and ensure accurate laboratory notebook, record keeping, and data collection.

The applicant is expected to perform independent data analysis, and reporting and documenting data in written and oral formats. Opportunities for intellectual input and contribution to manuscripts are readily available. The position will have opportunity to interact with a wide range of clinicians and scientific collaborators. The position will be supervised by the Center Director (Dr. Keith Ligon) and Associate Director (Dr. Kin-Hoe Chow).

SUPERVISORY RESPONSIBILITIES:

The applicant will lead and maintain a professional laboratory and vivarium environment required for various in vitro and in vivo research activities. The applicant will train/guide/assist new and junior lab members for commonly performed laboratory and animal related techniques and ensure accurate laboratory notebook, record keeping, and data collection.

Qualifications

BS in Biology, Animal Science, or closely related field;
Experience with wet bench techniques, flow cytometry, tissue culture methods, xenograft modeling, in vivo imaging, and small animal surgeries is highly preferred
Comprehensive understanding of research animal care of mice, including ability of handling mice and observing them for general health and overall wellbeing.
Proficiency in several of the following in vivo techniques, including: IV, SQ, IP, Cardiac Punctures, Retro-Orbital injections and bleeds, Anesthesia using Isofluorane, Euthanasia using CO2, Necropsy, Harvesting of tissues.
Proper record keeping, exceptional attention to detail is a must.
6 years of related work experience

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Employment Type

full time

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