Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Robert and Rene Belfer Center for Applied Cancer Science is an integrative research center within Dana-Farber Cancer Institute. Our mission is to accelerate Oncology drug discovery & development. We work with both industry and academic partners and apply industrial capabilities to cutting edge academic/clinical oncology research.
Position Summary: The In Vivo Research Associate will work closely with the preclinical and clinical scientists to design and execute oncology related mouse studies using bioluminescence (BLI) imaging as well as the entire spectrum of conventional (e.g., caliper measurements, clinical scoring) endpoints to evaluate pre-clinical novel cancer therapies. Must be able to work in a team environment and contribute to other studies. May be asked to assist in some technical support duties. Must be able to understand and follow the Animal Resource Facilities standard operating procedures and DFCI institutional guidelines and policies. Individual must understand and follow the local, state, federal and regulations and guidelines. The candidate will be part of project teams focused on identifying novel targets and therapies for cancer drug development. He/ She will contribute hands-on to the execution of both in vivo and ex vivo PD Biomarker studies in mouse models of cancer.
Assist with the establishment and maintenance of mouse cancer models (e.g. by injection or minor / major surgery).
Build of syngeneic, xenograft, PDX and orthotopic mouse cancer models
Perform mouse in vivo animal procedures, including dosing animals by various routes (e.g. oral, intravenous, intraperitoneal, etc), measuring tumors by calipers, non-invasive imaging (bioluminescent imaging)
Perform efficacy and tolerability testing in mouse cancer models
Breeding and genotyping of GEMMs
Animal health monitoring
Mouse necropsy and tissue collection
Routine handling, restraint, identification (including ear notching, tagging, tattooing, and toe clipping) and sexing of common laboratory animals. Ability to distinguish various common laboratory animal strains in accordance with standardized genetic nomenclature and phenotype identification.
Cell culturing techniques and subcutaneous implantation of cell and tumor grafts
Data recording, data analysis, reporting and interpretation
Contribute to overall vivarium organization and IACUC protocol
BS in biological sciences or equivalent
LAT certification preferred
1 year research experience in academic and/or pharmaceutical/biotech environment preferred
Ability to work in a team environment
Proficiency with in vivo databases, Graph Pad Prism and PowerPoint is desirable
Working Conditions: (include physical efforts when necessary)
After receiving specific training, this position will be required to occasionally work in the ABSL-2/3 suite treating and monitoring study animals.
All aspects of this position expose personnel to animal fur and dander, which may be hazardous to those with allergic conditions. Disinfectants, detergents and soaps are used in the daily sanitation assignments.
Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision, depth perception, and the ability to adjust focus.
Operation of centrifuge, anesthesia machine, autoclave, heat lamp, restrainer, tumor caliper, scales, barcode scanners and ATP luminometers.
The position is located at 360 Longwood Ave., Boston, MA
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.